Ion channel subunits

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Calcium- and sodium-activated potassium channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Calcium- and sodium-activated potassium channels K+ KCa1.1
Calcium- and sodium-activated potassium channels K+ KCa2.1
Calcium- and sodium-activated potassium channels K+ KCa2.2
Calcium- and sodium-activated potassium channels K+ KCa2.3
Calcium- and sodium-activated potassium channels K+ KCa3.1
Calcium- and sodium-activated potassium channels K+ KNa1.1
Calcium- and sodium-activated potassium channels K+ KNa1.2
Calcium- and sodium-activated potassium channels K+ KCa5.1
CatSper and Two-Pore channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
CatSper and Two-Pore channels Ca2+ CatSper1
CatSper and Two-Pore channels Ca2+ CatSper2
CatSper and Two-Pore channels Ca2+ CatSper3
CatSper and Two-Pore channels Ca2+ CatSper4
CatSper and Two-Pore channels Ca2+ TPC1
CatSper and Two-Pore channels Ca2+ TPC2
Cyclic nucleotide-regulated channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Cyclic nucleotide-regulated channels See comments below CNGA1
Cyclic nucleotide-regulated channels See comments below CNGA2
Cyclic nucleotide-regulated channels See comments below CNGA3
Cyclic nucleotide-regulated channels See comments below CNGA4
Cyclic nucleotide-regulated channels See comments below CNGB1
Cyclic nucleotide-regulated channels See comments below CNGB3
Cyclic nucleotide-regulated channels See comments below HCN1
Cyclic nucleotide-regulated channels See comments below HCN2
Cyclic nucleotide-regulated channels See comments below HCN3
Cyclic nucleotide-regulated channels See comments below HCN4
Comments: Most of these channels are permeable to sodium, potassium and calcium ions, however the main physiological ion has yet to be definitively established.
Inwardly rectifying potassium channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Inwardly rectifying potassium channels K+ Kir1.1
Inwardly rectifying potassium channels K+ Kir2.1
Inwardly rectifying potassium channels K+ Kir2.2
Inwardly rectifying potassium channels K+ Kir2.3
Inwardly rectifying potassium channels K+ Kir2.4
Inwardly rectifying potassium channels K+ Kir3.1
Inwardly rectifying potassium channels K+ Kir3.2
Inwardly rectifying potassium channels K+ Kir3.3
Inwardly rectifying potassium channels K+ Kir3.4
Inwardly rectifying potassium channels K+ Kir4.1
Inwardly rectifying potassium channels K+ Kir4.2
Inwardly rectifying potassium channels K+ Kir5.1
Inwardly rectifying potassium channels K+ Kir6.1
Inwardly rectifying potassium channels K+ Kir6.2
Inwardly rectifying potassium channels K+ Kir7.1
Ryanodine receptors
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Ryanodine receptors RyR1
Ryanodine receptors RyR2
Ryanodine receptors RyR3
Transient Receptor Potential channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Transient Receptor Potential channels See comments below TRPA1
Transient Receptor Potential channels See comments below TRPC1
Transient Receptor Potential channels See comments below TRPC2
Transient Receptor Potential channels See comments below TRPC3
Transient Receptor Potential channels See comments below TRPC4
Transient Receptor Potential channels See comments below TRPC5
Transient Receptor Potential channels See comments below TRPC6
Transient Receptor Potential channels See comments below TRPC7
Transient Receptor Potential channels See comments below TRPM1
Transient Receptor Potential channels See comments below TRPM2
Transient Receptor Potential channels See comments below TRPM3
Transient Receptor Potential channels See comments below TRPM4
Transient Receptor Potential channels See comments below TRPM5
Transient Receptor Potential channels See comments below TRPM6
Transient Receptor Potential channels See comments below TRPM7
Transient Receptor Potential channels See comments below TRPM8
Transient Receptor Potential channels See comments below TRPML1
Transient Receptor Potential channels See comments below TRPML2
Transient Receptor Potential channels See comments below TRPML3
Transient Receptor Potential channels See comments below TRPP1
Transient Receptor Potential channels See comments below TRPP2
Transient Receptor Potential channels See comments below TRPP3
Transient Receptor Potential channels See comments below TRPV1
Transient Receptor Potential channels See comments below TRPV2
Transient Receptor Potential channels See comments below TRPV3
Transient Receptor Potential channels See comments below TRPV4
Transient Receptor Potential channels See comments below TRPV5
Transient Receptor Potential channels See comments below TRPV6
Comments: Most of these channels are permeable to sodium, potassium and calcium ions, however the main physiological ion has yet to be definitively established.
Two P domain potassium channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Two P domain potassium channels K+ K2P1.1
Two P domain potassium channels K+ K2P2.1
Two P domain potassium channels K+ K2P3.1
Two P domain potassium channels K+ K2P4.1
Two P domain potassium channels K+ K2P5.1
Two P domain potassium channels K+ K2P6.1
Two P domain potassium channels K+ K2P7.1
Two P domain potassium channels K+ K2P9.1
Two P domain potassium channels K+ K2P10.1
Two P domain potassium channels K+ K2P12.1
Two P domain potassium channels K+ K2P13.1
Two P domain potassium channels K+ K2P15.1
Two P domain potassium channels K+ K2P16.1
Two P domain potassium channels K+ K2P17.1
Two P domain potassium channels K+ K2P18.1
Voltage-gated calcium channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Voltage-gated calcium channels Ca2+ Cav1.1
Voltage-gated calcium channels Ca2+ Cav1.2
Voltage-gated calcium channels Ca2+ Cav1.3
Voltage-gated calcium channels Ca2+ Cav1.4
Voltage-gated calcium channels Ca2+ Cav2.1
Voltage-gated calcium channels Ca2+ Cav2.2
Voltage-gated calcium channels Ca2+ Cav2.3
Voltage-gated calcium channels Ca2+ Cav3.1
Voltage-gated calcium channels Ca2+ Cav3.2
Voltage-gated calcium channels Ca2+ Cav3.3
Voltage-gated potassium channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Voltage-gated potassium channels K+ Kv1.1
Voltage-gated potassium channels K+ Kv1.2
Voltage-gated potassium channels K+ Kv1.3
Voltage-gated potassium channels K+ Kv1.4
Voltage-gated potassium channels K+ Kv1.5
Voltage-gated potassium channels K+ Kv1.6
Voltage-gated potassium channels K+ Kv1.7
Voltage-gated potassium channels K+ Kv1.8
Voltage-gated potassium channels K+ Kv2.1
Voltage-gated potassium channels K+ Kv2.2
Voltage-gated potassium channels K+ Kv3.1
Voltage-gated potassium channels K+ Kv3.2
Voltage-gated potassium channels K+ Kv3.3
Voltage-gated potassium channels K+ Kv3.4
Voltage-gated potassium channels K+ Kv4.1
Voltage-gated potassium channels K+ Kv4.2
Voltage-gated potassium channels K+ Kv4.3
Voltage-gated potassium channels K+ Kv5.1
Voltage-gated potassium channels K+ Kv6.1
Voltage-gated potassium channels K+ Kv6.2
Voltage-gated potassium channels K+ Kv6.3
Voltage-gated potassium channels K+ Kv6.4
Voltage-gated potassium channels K+ Kv7.1
Voltage-gated potassium channels K+ Kv7.2
Voltage-gated potassium channels K+ Kv7.3
Voltage-gated potassium channels K+ Kv7.4
Voltage-gated potassium channels K+ Kv7.5
Voltage-gated potassium channels K+ Kv8.1
Voltage-gated potassium channels K+ Kv8.2
Voltage-gated potassium channels K+ Kv9.1
Voltage-gated potassium channels K+ Kv9.2
Voltage-gated potassium channels K+ Kv9.3
Voltage-gated potassium channels K+ Kv10.1
Voltage-gated potassium channels K+ Kv10.2
Voltage-gated potassium channels K+ Kv11.1
Voltage-gated potassium channels K+ Kv11.2
Voltage-gated potassium channels K+ Kv11.3
Voltage-gated potassium channels K+ Kv12.1
Voltage-gated potassium channels K+ Kv12.2
Voltage-gated potassium channels K+ Kv12.3
Voltage-gated proton channel
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Voltage-gated proton channel H+ Hv1
Voltage-gated sodium channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Voltage-gated sodium channels Na+ Nav1.1
Voltage-gated sodium channels Na+ Nav1.2
Voltage-gated sodium channels Na+ Nav1.3
Voltage-gated sodium channels Na+ Nav1.4
Voltage-gated sodium channels Na+ Nav1.5
Voltage-gated sodium channels Na+ Nav1.6
Voltage-gated sodium channels Na+ Nav1.7
Voltage-gated sodium channels Na+ Nav1.8
Voltage-gated sodium channels Na+ Nav1.9
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