terfenadine

Ligand id: 2608

Name: terfenadine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 43.7
Molecular weight 471.31
XLogP 7.11
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA)
Withdrawn drug? Yes
IUPAC Name
1-(4-tert-butylphenyl)-4-[4-[hydroxy-di(phenyl)methyl]piperidin-1-yl]butan-1-ol
International Nonproprietary Names
INN number INN
3674 terfenadine
Synonyms
RMI-9918 | Seldane® | Triludan®
Comments
Due to adverse effects on cardiac function, terfenadine has largely been superseded by its carboxylic acid metabolite fexofenadine. Terfenadine was completely withdrawn in the US in 1998.
Database Links
BindingDB Ligand
CAS Registry No. 50679-08-8
ChEBI
ChEMBL Ligand
DrugBank Ligand
GtoPdb PubChem SID
PubChem CID
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