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Targets Associated to Immuno Cell Types - Innate lymphoid cells

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The Innate lymphoid cells category includes the following Cell Ontology parent terms:

innate lymphoid cell () - A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses.

GPCRs
GtoPdb receptor name (family) Cell Type Association Comments Cell Ontology Associations Immunopharmacology Comments
DP2 receptor
(Prostanoid receptors)
Expression of the DP2 receptor is restricted to eosinophils, basophils, Th2 cells, and innate lymphoid cells.
  • innate lymphoid cell (CL:0001065)
The DP2 receptor (a.k.a. CRTH2, chemoattractant receptor-homologous molecule expressed on T-helper 2 cells) is expressed exclusively by a range of human immune cells including Th2 cells, basophils, eosinophils and innate lymphoid cells [2,5] ...
C3a receptor
(Complement peptide receptors)
Some lamina propria-derived type 3 innate lymphoid cells express C3aR in the mouse.
  • group 3 innate lymphoid cell (CL:0001071)
Complement C3a receptor 1 is the receptor for complement factor C3a, a component of the alternative complement cascade. It can have pro-inflammatory actions, but can also counteract the proinflammatory effects of C5a.
The complement system plays a critical role intestinal immune homeostasis. In particular, C3 and the C3aR have been identified as being involved in regulating the intestinal immune response during chronic colitis [7,9] ...
Enzymes
GtoPdb receptor name (family) Cell Type Association Comments Cell Ontology Associations Immunopharmacology Comments
dual oxidase 1
(NADPH oxidases)
DUOX1 expression has been reported in ILCs.
  • innate lymphoid cell (CL:0001065)
DUOX1 participates in innate immune responses to epithelial injury and allergens, and in the development of allergic diseases [8] ...
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